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  • 1960 Born
  • 1985 Diploma Thesis, University of Berne
  • 1985-1988 PhD Thesis with Prof. T. Seebeck at the Institute of General Microbiology of the University of Berne
    (Subject: Cytoskeleton of T. brucei)
  • 1988-1991 Postdoc with Prof. G. Schatz at the Biozentrum of the University of Basel
    (Subject: Mitochondrial protein import in yeast)
  • 1991-1993 Independent Postdoc funded by the SNF with Prof. N. Agabian at UCSF
    (Subject: Mitochondrial tRNA import in T. brucei)
  • 1993-1996 Group leader (Biocenter Fellow) at the Biozentrum of the University of Basel
    (Subject: Mitochondrial tRNA import in T. brucei)
  • 1996 Habilitation in Biochemistry at the University of Basel
  • 1993-2004 Group leader (Max-Cloetta Fellow) at the Department of Biology of the University of Fribourg
    (Subject: Mitochondrial biogenesis in T. brucei)
  • 2004-2007 Associate Professor at the Department of Biology of the University of Fribourg
  • 2008- Full Professor of Biochemistry at the Deparmtent of Chemistry and Biochemistry of the University of Berne

 Mitochondrial biogenesis using the parasitic protozoa Trypanosoma brucei as a model system

  • mitochondrial tRNA import and its consequences
  • mitochondrial protein import
  • mitochondrial gene expression

 

Journal Article

Käser, Sandro; Willemin, Mathilde Stéphanie; Schnarwiler, Felix; Schimanski, Bernd; Poveda-Huertes, Daniel; Oeljeklaus, Silke; Haenni, Beat; Zuber, Benoît; Warscheid, Bettina; Meisinger, Christof; Schneider, André (2017). Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei. PLoS pathogens, 13(12), e1006808. Public Library of Science 10.1371/journal.ppat.1006808

Niemann, Moritz; Harsman, Anke Judith; Mani, Jan; Peikert, Christian D.; Oeljeklaus, Silke; Warscheid, Bettina; Wagner, Richard; Schneider, André (2017). tRNAs and proteins use the same import channel for translocation across the mitochondrial outer membrane of trypanosomes. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 114(37), E7679-E7687. National Academy of Sciences NAS 10.1073/pnas.1711430114

Peikert, Christian D.; Mani, Jan; Morgenstern, Marcel; Käser, Sandro; Knapp, Bettina; Wenger, Christoph; Harsman, Anke Judith; Oeljeklaus, Silke; Schneider, André; Warscheid, Bettina (2017). Charting organellar importomes by quantitative mass spectrometry. Nature communications, 8, p. 15272. Nature Publishing Group 10.1038/ncomms15272

Bruggisser, Julia; Käser, Sandro; Mani, Jan; Schneider, André (2017). Biogenesis of a mitochondrial outer membrane protein in Trypanosoma brucei : targeting signal and dependence on an unique biogenesis factor. Journal of biological chemistry, 292(8), pp. 3400-3410. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M116.755983

Mani, Jan; Rout, Samuel; Desy, Silvia Franziska; Schneider, André (2017). Mitochondrial protein import - Functional analysis of the highly diverged Tom22 orthologue of Trypanosoma brucei. Scientific Reports, 7(40738), p. 40738. Nature Publishing Group 10.1038/srep40738

Harsman, Anke Judith; Schneider, André (2017). Mitochondrial protein import in trypanosomes: Expect the unexpected. Traffic, 18(2), pp. 96-109. Wiley-Blackwell 10.1111/tra.12463

Harsman, Anke Judith; Oeljeklaus, Silke; Wenger, Christoph; Huot, Jonathan; Warscheid, Bettina; Schneider, André (2016). The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins. Nature communications, 7, p. 13707. Nature Publishing Group 10.1038/ncomms13707

Desy, Silvia Franziska; Mani, Jan; Harsman, Anke Judith; Käser, Sandro; Schneider, André (2016). TbLOK1/ATOM19 is a novel subunit of the noncanonical mitochondrial outer membrane protein translocase of Trypanosoma brucei. Molecular microbiology, 102(3), pp. 520-529. Blackwell Science 10.1111/mmi.13476

Käser, Sandro; Oeljeklaus, Silke; Týč, Jiří; Vaughan, Sue; Warscheid, Bettina; Schneider, André (2016). Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 113(31), E4467-E4475. National Academy of Sciences NAS 10.1073/pnas.1605497113

Mani, Jan; Meisinger, Chris; Schneider, André (2016). Peeping at TOMs—Diverse Entry Gates to Mitochondria Provide Insights into the Evolution of Eukaryotes. Molecular Biology and Evolution, 33(2), pp. 337-351. Oxford University Press 10.1093/molbev/msv219

Farine, Luce; Niemann, Moritz; Schneider, André; Bütikofer, Peter (2015). Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei. Scientific Reports, 5(1), p. 16787. Nature Publishing Group 10.1038/srep16787

Albisetti, Anna; Wiese, Sebastian; Schneider, André; Niemann, Moritz (2015). A component of the mitochondrial outer membrane proteome of T. brucei probably contains covalent bound fatty acids. Experimental parasitology, 155, pp. 49-57. Elsevier 10.1016/j.exppara.2015.05.006

de Macêdo, Juan P.; Schumann-Burkard, Gabriela; Niemann, Moritz; Barrett, Michael P.; Vial, Henri; Mäser, Pascal; Roditi, Isabel; Schneider, André; Bütikofer, Peter; Horn, David (2015). An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei. PLoS pathogens, 11(5), e1004875. Public Library of Science 10.1371/journal.ppat.1004875

Mani, Jan; Desy, Silvia Franziska; Niemann, Moritz; Chanfon, Astrid; Oeljeklaus, Silke; Pusnik, Mascha; Schmidt, Oliver; Gerbeth, Carolin; Meisinger, Chris; Warscheid, Bettina; Schneider, André (2015). Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances. Nature communications, 6(6646), p. 6646. Nature Publishing Group 10.1038/ncomms7646

Schneider, André; Schnarwiler, Felix (2014). Parasite Reveals Mitochondrial Inheritance Machinery. CHIMIA, 68(10), p. 749. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2014.749

Schnarwiler, Felix; Niemann, Moritz; Doiron, Nicholas; Harsman, Anke Judith; Käser, Sandro; Mani, Jan; Chanfon, Astrid; Dewar, C. E.; Oeljeklaus, S.; Jackson, Christopher; Pusnik, M.; Schmidt, O.; Meisinger, C.; Hiller, S.; Warscheid, B.; Schnaufer, A. C.; Ochsenreiter, Torsten; Schneider, André (2014). Trypanosomal TAC40 constitutes a novel subclass of mitochondrial -barrel proteins specialized in mitochondrial genome inheritance. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 111(21), pp. 7624-7629. National Academy of Sciences NAS 10.1073/pnas.1404854111

Cristodero, Marina; Mani, Jan; Oeljeklaus, Silke; Aeberhard, Lukas; Hashimi, Hassan; Ramrath, David J. F.; Lukeš, Julius; Warscheid, Bettina; Schneider, André (2013). Mitochondrial translation factors of Trypanosoma brucei: elongation factor-Tu has a unique subdomain that is essential for its function. Molecular microbiology, 90(4), pp. 744-755. Oxford: Blackwell Science 10.1111/mmi.12397

Niemann, Moritz; Wiese, Sebastian; Mani, Jan; Chanfon, Astrid; Jackson, Christopher; Meisinger, Christof; Warscheid, Bettina; Schneider, André (2013). Mitochondrial Outer Membrane Proteome of Trypanosoma brucei Reveals Novel Factors Required to Maintain Mitochondrial Morphology. Molecular & cellular proteomics, 12(2), pp. 515-528. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/mcp.M112.023093

Desy, Silvia; Schneider, André; Mani, Jan (2012). Trypanosoma brucei has a canonical mitochondrial processing peptidase. Molecular and biochemical parasitology, 185(2), pp. 161-164. Amsterdam: Elsevier 10.1016/j.molbiopara.2012.07.005

Harsman, Anke; Niemann, Moritz; Pusnik, Mascha; Schmidt, Oliver; Burmann, Björn M.; Hiller, Sebastian; Meisinger, Chris; Schneider, André; Wagner, Richard (2012). Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase. NEW PERSPECTIVES FROM COMPARATIVE SINGLE CHANNEL ELECTROPHYSIOLOGY. Journal of biological chemistry, 287(37), pp. 31437-31445. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.392118

Pusnika, Mascha; Mania, Jan; Schmidt, Oliver; Niemanna, Moritz; Oeljeklaus, Silke; Schnarwiler, Felix; Warscheid, Bettina; Lithgow, Trevor; Meisinger, Chris; Schneider, André (2012). An essential novel component of the noncanonical mitochondrial outer membrane protein import system of trypanosomatids. Molecular biology of the cell, 23(17), pp. 3420-3428. Bethesda, Md.: American Society for Cell Biology 10.1091/mbc.E12-02-0107

Pusnik, Mascha; Schmidt, Oliver; Perry, Andrew; Oeljeklaus, Silke; Niemann, Moritz; Warscheid, Bettina; Meisinger, Chris; Lithgow, Trevor; Schneider, André (2012). Tom40 is likely common to all mitochondria Response. Current Biology, 22(12), R481-R482. Cambridge, Mass.: Cell Press 10.1016/j.cub.2012.03.056

Pusnik, Mascha; Schneider, André (2012). A Trypanosomal Pentatricopeptide Repeat Protein Stabilizes the Mitochondrial mRNAs of Cytochrome Oxidase Subunits 1 and 2. Eukaryotic cell, 11(1), pp. 79-87. Washington, D.C.: American Society for Microbiology ASM 10.1128/EC.05213-11

Pusnik, Mascha; Schmidt, Oliver; Perry, Andrew J.; Oeljeklaus, Silke; Niemann, Moritz; Warscheid, Bettina; Lithgow, Trevor; Meisinger, Chris; Schneider, André (2011). Mitochondrial preprotein translocase of trypanosomatids has a bacterial origin. Current Biology, 21(20), pp. 1738-1743. Cambridge, Mass.: Cell Press 10.1016/j.cub.2011.08.060

Tschopp, Florence; Charrière, Fabien; Schneider, André (2011). In vivo study in Trypanosoma brucei links mitochondrial transfer RNA import to mitochondrial protein import. EMBO reports, 12(8), pp. 825-832. London: Nature Publishing Group 10.1038/embor.2011.111

Niemann, Moritz; Schneider, André; Cristodero, Marina (2011). Mitochondrial translation in trypanosomatids: a novel target for chemotherapy? Trends in parasitology, 27(10), pp. 429-433. Oxford: Elsevier Current Trends 10.1016/j.pt.2011.03.011

Schneider, André (2011). Mitochondrial tRNA import and its consequences for mitochondrial translation. Annual review of biochemistry, 80(1), pp. 1033-1053. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev-biochem-060109-092838

Rettig, Jochen; Wang, Yimu M.; Schneider, André; Ochsenreiter, Torsten (2011). Dual targeting of isoleucyl-tRNA synthetase in Trypanosoma brucei is mediated through alternative trans-splicing. Nucleic acids research, 40(3), pp. 1299-1306. London: Information Retrieval Ltd. 10.1093/nar/gkr794

Aeby, Eric; Ullu, Elisabetta; Yepiskoposyan, Hasmik; Schimanski, Bernd; Roditi, Isabel; Mühlemann, Oliver; Schneider, André (2010). tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans. Nucleic acids research, 38(17), pp. 5833-5843. London: Information Retrieval Ltd. 10.1093/nar/gkq345

Cristodero, Marina; Seebeck, Thomas; Schneider, André (2010). Mitochondrial translation is essential in bloodstream forms of Trypanosoma brucei. Molecular microbiology, 78(3), pp. 757-769. Oxford: Blackwell Science 10.1111/j.1365-2958.2010.07368.x

Pino, Paco; Aeby, Eric; Foth, Bernardo Javier; Sheiner, Lilach; Soldati, Thierry; Schneider, André; Soldati-Favre, Dominique (2010). Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNAMet formylation in Apicomplexa. Molecular microbiology, 76(3), pp. 706-718. Oxford: Blackwell Science 10.1111/j.1365-2958.2010.07128.x

Lithgow, Trevor; Schneider, André (2010). Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes. Philosophical transactions of the Royal Society. Series B - biological sciences, 365(1541), pp. 799-817. London: Royal Society of London 10.1098/rstb.2009.0167

Bruske, Ellen Inga; Sendfeld, Franziska; Schneider, André (2009). Thiolated tRNAS of Trypanosoma brucei are imported into mitochondria and dethiolated after import. Journal of biological chemistry, 284(52), pp. 36491-36499. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M109.064527

Español, Yaiza; Thutb, Daniel; Schneider, André; de Pouplana, Lluís Ribas (2009). A mechanism for functional segregation of mitochondrial and cytosolic genetic codes. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 106(46), pp. 19420-19425. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.0909937106

Aeby, Eric; Seidel, Viktoria; Schneider, André (2009). The selenoproteome is dispensable in bloodstream forms of Trypanosoma brucei. Molecular and biochemical parasitology, 168(2), pp. 191-193. Amsterdam: Elsevier 10.1016/j.molbiopara.2009.08.007

Signorell, Aita; Gluenz, Eva; Rettig, Jochen; Schneider, André; Shaw, Michael; Gull, Keith; Bütikofer, Peter (2009). Perturbation of phosphatidylethanolamine synthesis affects mitochondrial morphology and cell-cycle progression in procyclic-form Trypanosoma brucei. Molecular microbiology, 72(4), pp. 1068-79. Oxford: Blackwell Science 10.1111/j.1365-2958.2009.06713.x

Charrière, Fabien; O'Donoghue, Patrick; Helgadóttir, Sunna; Maréchal-Drouard, Laurence; Cristodero, Marina; Horn, Elke; Söll, Dieter; Schneider, André (2009). Dual Targeting of a tRNAAsp Requires Two Different Aspartyl-tRNA Synthetases in Trypanosoma brucei. Journal of biological chemistry, 284(24), pp. 16210-16217. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M109.005348

Aeby, Eric; Paliourab, Sotiria; Pusnik, Mascha; Marazzia, Janine; Lieberman, Allyson; Ullu, Elisabetta; Söll, Dieter; Schneider, André (2009). The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 106(13), pp. 5088-5092. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.0901575106

Pusnik, Mascha; Charrière, Fabien; Mäser, Pascal; Waller, Ross F.; Dagley, Michael J.; Lithgow, Trevor; Schneider, André (2009). The Single Mitochondrial Porin of Trypanosoma brucei is the Main Metabolite Transporter in the Outer Mitochondrial Membrane. Molecular Biology and Evolution, 26(3), pp. 671-680. Oxford: Oxford University Press 10.1093/molbev/msn288

Schneider, André; Bursac, Dejan; Lithgow, Trevor (2008). The direct route: a simplified pathway for protein import into the mitochondrion of trypanosomes. Trends in cell biology, 18(1), pp. 12-18. Cambridge: Elsevier Current Trends 10.1016/j.tcb.2007.09.009

Conference or Workshop Item

Cristodero, Marina; Fricker, Roger; Schneider, André; Polacek, Norbert (5 September 2016). Biology of tRNAs in Trypanosoma brucei during stress (Unpublished). In: 26th tRNA Conference. Jeju, Korea. 04.-08.09.2016.

Schneider, André (4 September 2016). The non-canonical mitochondrial inner membrane protein translocase of trypanosomatids contains two essential rhomboid-like proteins (Unpublished). In: BSP Trypanosomiasis & Leishmaniasis Seminar 2016. Ceske Budejovice, Czech Republic. 04.-07.09.2016.

Schneider, André (31 October 2015). 1+1=1 - Wie komplexe Zellen entstanden sind (Unpublished). In: BioChemie am Samstag - Vortragsreihe. Universität Bern, Bern. 31.10.2015.

Schneider, André (12 October 2015). What can a unicellular parasite tell us about mitochondrial biogenesis? (Unpublished). In: FEBS/EMBO course: Mitochondria in life, death and disease. Fodeles, Kreta, Griechenland. 12.-16.10.2015.

Schneider, André (3 September 2015). What can a parasite tell us about mitochondrial biogenesis (Unpublished). In: CUSO doctoral program Molecular Plant Sciences: Endosymbiotic organelles. Universität Neuchâtel, Neuchâtel, Schweiz. 03.-04.09.2015.

Schneider, André (4 December 2014). What can a unicellular parasite tell us about mitochondrial biogenesis? (Unpublished). In: Seminar at Monash University, Australia. Melbourne, Australia. 04.12.2014.

Schneider, André (6 October 2014). What can a parasite tell us about mitochondrial biogenesis? (Unpublished). In: Freudenstadt Meeting (Retreat Group Prof. N. Pfanner). Freudenstadt, Germany. 06.10.-08.10.2014.

Schneider, André (2 September 2014). What can a parasite tell us about mitochondrial biogenesis? (Unpublished). In: SwissMito Meeting 2014. Kandersteg, Schweiz. 02.09.-03.09.2014.

Schneider, André (8 June 2014). What can a parasite tell us about mitochondrial biogenesis? (Unpublished). In: Gordon research conference: Host parasite interactions. Newport, USA. 08.06.-13.06.2014.

Schneider, André (8 May 2014). What can a parasite tell us about mitochondrial biogenesis? (Unpublished). In: Seminar at the University of Glasgow. University of Glasgow, Glasgow, UK. 08.05.2014.

Schneider, André (17 December 2013). What a unicellular parasite can tell us about mitochondrial biogenesis? (Unpublished). In: What a unicellular parasite can tell us about mitochondrial biogenesis?. Biozentrum Basel. 17.12.2013.

Schneider, André (25 September 2013). What a unicellular parasite can tell us about mitochondrial biogenesis? (Unpublished). In: What a unicellular parasite can tell us about mitochondrial biogenesis?. Universität Köln. 25.09.2013.

Schneider, André (8 September 2013). A conserved mitochondrial outer membrane protein mediates kDNA maintenace in Trypanosoma brucei (Unpublished). In: 24th Annual Molecular Parasitology Meeting. Woods Hole, USA. 08.-12.09.2013.

Schneider, André (13 June 2013). Trypanosoma brucei a model system to study mitochondrial biogenesis (Unpublished). In: Mitocross Meeting. Universität Strasbourg, Frankreich. 13.06.2013.

Pusnik, Mascha; Niemann, Moritz; Wiese, Sebastian; Schmidt, Oliver; Perry, Andrew J.; Oeljeklaus, Silke; Lithgow, Trevor; Warscheid, Bettina; Meisinger, Chris; Schneider, André (2012). The non-canonical preprotein translocase of the mitochondrial outer membrane. In: FEBS/EMBO course, Mitochondria in life, death and disease 2012, Abstractbook. Crete, Greece. 9-13 May 2012.

Mani, Jan; Pusnik, Mascha; Niemann, Moritz; Wiese, Sebastian; Schmidt, Oliver; Oeljeklaus, Silke; Warscheid, Bettina; Meisinger, Chris; Schneider, André (2012). Composition and functional analysis of the trypanosomal ATOM protein import complex. In: FEBS/EMBO course, Mitochondria in life, death and disease 2012, Abstractbook.

Schneider, André (2012). The non-canonical preprotein translocase of the mitochondrial outer membrane. In: Gordon Research Conference, Host parasite Interactions 2012, Abstract.

Niemann, Moritz; Wiese, Sebastian; Warscheid, Bettina; Meisinger, Chris; Schneider, André (2012). The proteome of the mitochondrial outer membrane of T. brucei. In: Gordon Research Conference, Mitochondria and Chloroplasts 2012, Abstract.