Links

  • 1993 – 1998: Diploma in Chemistry, University of Zürich. Diploma thesis: synthesis of unnatural polyamines (group of late Prof. Dr. Manfred Hesse).
  • 1998 – 2003: PhD thesis, University of Basel. Synthesis and study of iron porphyrin model compounds as mimics for cytochrome P450 enzymes (group of Prof. Dr. em. Wolf-D. Woggon).
  • 2003 – 2004: Postdoctoral Research Fellow with Prof. Ian Paterson FRS, Department of Chemistry, University of Cambridge, UK. Working on the total synthesis of the marine, anti-cancer compound Peloruside A.
  • 2004 – 2005: Postdoctoral Research Fellow with Prof. Sarah C. R. Lummis, Department of Biochemistry, University of Cambridge, UK. Study of mutant serotonin 5-HT3 receptors as models for heteromeric ligand-gated ion channels.
  • 2006 – 2009: Lecturer in Chemical Biology, Department of Chemistry, University of Warwick, UK.
  • 2010 – 2015: Swiss National Science Foundation Professor (Assistant Professor) in Bioorganic Chemistry, Department of Chemistry & Biochemistry, University of Bern.
  • 2016 – present: Lecturer and Group Leader at the Institute of Biochemistry and Molecular Medicine (IBMM), University of Bern.

The general theme of our research is the development of small molecular tools for the cellular study and chemical modification of ion channels, receptors and transporters, thereby complementing molecular biology techniques and offering attractive alternatives to the biological research community. We mainly focus on:

  • Fluorescent receptor ligands (antagonists and agonists)
  • Photo-crosslinking probes
  • Fluorescent turn-on probes for protein labelling

Journal Article

Kappel, Sven; Kilch, Tatiana; Baur, Roland; Lochner, Martin; Peinelt, Christine (2020). The Number and Position of Orai3 Units within Heteromeric Store-Operated Ca2+ Channels Alter the Pharmacology of ICRAC. International Journal of Molecular Sciences, 21(7) MDPI 10.3390/ijms21072458

Beswick, Paul; Wahab, Ben; Honey, Mark A.; Paradowski, Michael; Ke, Jiang; Lochner, Martin; Murrell-Lagnado, Ruth D.; Thompson, Andrew J. (2019). A challenge finding P2X1 and P2X4 ligands. Neuropharmacology, 157(107674), p. 107674. Elsevier 10.1016/j.neuropharm.2019.107674

Jack, Thomas; Leuenberger, Michele; Ruepp, Marc-David; Vernekar, Sanjeev Kumar V; Thompson, Andrew James; Braga-Lagache, Sophie; Heller, Manfred; Lochner, Martin (2019). Mapping the Orthosteric Binding Site of the Human 5-HT3 Receptor Using Photo-crosslinking Antagonists. ACS chemical neuroscience, 10(1), pp. 438-450. American Chemical Society 10.1021/acschemneuro.8b00327

Ozhathil, Lijo Cherian; Delalande, Clémence Marie Sandrine; Bianchi, Beatrice; Nemeth, Gabor; Kappel, Sven; Thomet, Urs; Ross, Daniela; Simonin, Céline; Rubin, Matthias; Gertsch, Jürg; Lochner, Martin; Peinelt, Christine; Reymond, Jean-Louis; Abriel, Hugues (2018). Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. British journal of pharmacology, 175(12), pp. 2504-2519. Wiley-Blackwell 10.1111/bph.14220

Ruepp, Marc-David; Wei, Hao; Leuenberger, Michele; Lochner, Martin; Thompson, Andrew James (2017). The binding orientation of structurally-related ligands can differ; A cautionary note. Neuropharmacology, 119, pp. 48-61. Elsevier 10.1016/j.neuropharm.2017.01.023

Thompson, Andrew J.; Metzger, Simon; Lochner, Martin; Ruepp, Marc-David (2017). The binding orientation of epibatidine at α7 nACh receptors. Neuropharmacology, 116, pp. 421-428. Elsevier 10.1016/j.neuropharm.2017.01.008

Mu, Linjing; Müller Herde, Adrienne; Rüefli, Pascal; Sladojevich, Filippo; Sephton, Selena Milicevic; Krämer, Stefanie D.; Thompson, Andrew James; Schibli, Roger; Ametamey, Simon M.; Lochner, Martin (2016). Synthesis and Pharmacological Evaluation of [11C]granisetron and [18F]fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging. ACS chemical neuroscience, 7(11), pp. 1552-1564. American Chemical Society 10.1021/acschemneuro.6b00192

Lochner, Martin; Thompson, Andrew James (2016). The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors. Neuropharmacology, 108, pp. 220-228. Elsevier 10.1016/j.neuropharm.2016.04.027

Leuenberger, Michele; Ritler, Andreas; Simonin, Alexandre; Hediger, Matthias; Lochner, Martin (2016). Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes. ACS chemical neuroscience, 7(5), pp. 534-539. American Chemical Society 10.1021/acschemneuro.5b00311

Knight, Anthony; Hemmings, Jennifer Luise; Winfield, Ian; Leuenberger, Michele; Frattini, Eugenia; Frenguelli, Bruno G.; Dowell, Simon J.; Lochner, Martin; Ladds, Graham (2016). Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. Journal of medicinal chemistry, 59(3), pp. 947-964. American Chemical Society 10.1021/acs.jmedchem.5b01402

Lochner, Martin; Thompson, Andrew James (2015). Lighting up neuroscience. Neuropharmacology, 98, pp. 1-2. Elsevier 10.1016/j.neuropharm.2015.10.004

Barden, Adam O.; Goler, Adam S.; Humphreys, Sara C.; Tabatabaei, Samaneh; Lochner, Martin; Ruepp, Marc-David; Jack, Thomas; Simonin, Jonathan; Thompson, Andrew James; Jones, Jeffrey P.; Brozik, James A. (2015). Tracking individual membrane proteins and their biochemistry: The power of direct observation. Neuropharmacology, 98, pp. 22-30. Elsevier 10.1016/j.neuropharm.2015.05.003

Lochner, Martin; Thompson, Andrew James (2015). A review of fluorescent ligands for studying 5-HT3 receptors. Neuropharmacology, 98, pp. 31-40. Elsevier 10.1016/j.neuropharm.2015.04.002

Jack, Thomas; Simonin, Jonathan; Ruepp, Marc-David; Thompson, Andrew James; Gertsch, Jürg; Lochner, Martin (2015). Characterizing New Fluorescent Tools for Studying 5-HT3 Receptor Pharmacology. Neuropharmacology, 90, pp. 63-73. Elsevier 10.1016/j.neuropharm.2014.11.007

Lochner, Martin; Thompson, Andrew James (2014). The Antimalarial Drug Proguanil Is An Antagonist at 5-HT3 Receptors. Journal of pharmacology and experimental therapeutics, 351(3), pp. 674-684. American Society for Pharmacology and Experimental Therapeutics 10.1124/jpet.114.218461

Jack, Thomas; Ruepp, Marc-David; Thompson, Andrew J.; Mühlemann, Oliver; Lochner, Martin (2014). Synthesis and Characterization of Photoaffinity Probes that Target the 5-HT<SUB>3</SUB> Receptor. CHIMIA, 68(4), pp. 239-242. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2014.239

Hofer, Alexandre; Kovacs, Gergely; Zappatini, Anna; Leuenberger, Michele; Hediger, Matthias A.; Lochner, Martin (2013). Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorganic & medicinal chemistry, 21(11), pp. 3202-3213. Elsevier 10.1016/j.bmc.2013.03.037

Kanai, Yoshikatsu; Clemençon, Benjamin; Simonin, Alexandre; Leuenberger, Michele; Lochner, Martin; Weisstanner, Martin; Hediger, Matthias A. (2013). The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular aspects of medicine, 34(2-3), pp. 108-120. Elsevier 10.1016/j.mam.2013.01.001

Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J.Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin (2012). High-affinity fluorescent ligands for the 5-HT3 receptor. Bioorganic and medicinal chemistry letters, 22(2), pp. 1151-1155. New York, N.Y.: Pergamon 10.1016/j.bmcl.2011.11.097

Quek, Gracia X. J.; Lin, Diana; Halliday, Jill I.; Absalom, Nathan; Ambrus, Joseph I.; Thompson, Andrew J.; Lochner, Martin; Lummis, Sarah C. R.; McLeod, Malcolm D.; Chebib, Mary (2010). Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at alpha 4 beta 2 Nicotinic Acetylcholine Receptors. ACS chemical neuroscience, 1(12), pp. 796-809. Washington, D.C.: American Chemical Society 10.1021/cn100073x

Lochner, Martin; Lummis, Sarah C.R. (2010). Agonists and Antagonists Bind to an A-A Interface in the Heteromeric 5-HT3AB receptor. Biophysical journal, 98(8), pp. 1494-1502. Bethesda, Md.: Biophysical Society 10.1016/j.bpj.2009.12.4313

Vernekar, Sanjeev Kumar V.; Hallaq, Hasan Y.; Clarkson, Guy; Thompson, Andrew J.; Silvestri, Linda; Lummis, Sarah C. R.; Lochner, Martin (2010). Toward Biophysical Probes for the Serotonin 5-HT3 Receptor: Structure–Activity Relationship Study of Granisetron Derivatives. Journal of medicinal chemistry, 53(5), pp. 2324-2328. Easton, Pa.: American Chemical Society 10.1021/jm901827x

Lochner, Martin (2010). Expanding the Small Molecular Toolbox to Study Big Biomolecular Machines. CHIMIA, 64(4), pp. 241-246. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2010.241

Thompson, Andrew James; Lochner, Martin; Lummis, S.C.R. (2008). Loop B Is a Major Structural Component of the 5-HT3 Receptor. Biophysical journal, 95(12), pp. 5728-5736. Biophysical Society 10.1529/biophysj.108.135624

Thompson, Andrew James; Lochner, Martin; Lummis, S. C. R. (2007). The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT 3 receptors. British journal of pharmacology, 151(5), pp. 666-677. Wiley-Blackwell 10.1038/sj.bjp.0707238

Lochner, Martin (2004). The 39th EUCHEM Bürgenstock Conference on Stereochemistry (conference report). CHIMIA, 58, pp. 414-421. Bern: Schweizerische Chemische Gesellschaft

Lochner, Martin; Mu, Linjing; Woggon, Wolf-D. (2003). Remote Effects Modulating the Spin Equilibrium of the Resting State of Cytochrome P450cam –An Investigation Using Active Site Analogues. Advanced synthesis & catalysis, 345(6-7), pp. 743-765. Wiley-VCH 10.1002/adsc.200303011

Lochner, Martin; Meuwly, Markus; Woggon, Wolf-D. (2003). The origin of the low-spin character of the resting state of cytochrome P450cam investigated by means of active site analogues. Chemical communications, 2003(12), pp. 1330-1332. Royal Society of Chemistry 10.1039/b302274a

Robillard, Marc S.; Jansen, Bart A. J.; Lochner, Martin; Geneste, Hervé; Li, Yi; Brouwer, Jaap; Hesse, Manfred; Reedijk, Jan (2001). Mononuclear Tetraamineplatinum(II) Complexes: Synthesis, Anticancer Activity, DNA Binding, and Cellular Uptake. Helvetica chimica acta, 84(10), pp. 3023-3030. Verlag Helvetica Chimica Acta 10.1002/1522-2675(20011017)84:10<3023::AID-HLCA3023>3.0.CO;2-Z

Liao, Ying; Popaj, Kasim; Lochner, Martin; Geneste, Herve; Budriesi, Roberta; Chiarini, Alberto; Melchiorre, Carlo; Hesse, Manfred (2001). Analogues of polyamine alkaloids and their synthetic advantages. Il Farmaco, 56(1-2), pp. 127-131. Elsevier 10.1016/S0014-827X(01)01021-7

Lochner, Martin; Geneste, Hervé; Hesse, Manfred (1998). Allgemeiner Zugang zu Polyaminen mit Ethan-1,2-diamin-Einheiten: Synthese von nicht natürlich vorkommenden homologen und isomerenN1,4-Di(4-cumaroyl)sperminen. Helvetica chimica acta, 81(12), pp. 2270-2281. Verlag Helvetica Chimica Acta 10.1002/(SICI)1522-2675(19981216)81:12<2270::AID-HLCA2270>3.0.CO;2-#

Newspaper or Magazine Article

Lochner, Martin (2012). Tailor-made tools (feature); Micro machines. International Innovation, pp. 43-45.

Conference or Workshop Item

Leuenberger, Michele; Bernhard, Stephanie; Grossenbacher, Philipp; Stieger, Bruno; Lochner, Martin (6 September 2019). Synthesis of Fluorescent Tools to Better Understand the Canalicular Lipid Transporter System. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft

Preti, Barbara; Leuenberger, Michele; Lochner, Martin; Frenguelli, Bruno G.; Ladds, Graham (6 September 2019). Development of Molecular Tools for the Cellular Study of Adenosine A1 Receptors. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (6 September 2019). Diverse effects of halogenated 2-aminoethoxydiphenyl borate derivatives on store-operated calcium entry in breast cancer cells. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Dernic, Jan; Hediger, Matthias; Lochner, Martin (6 September 2019). Synthesis of functionalized probes based on GSK7975A to study SOCE. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft

Lochner, Martin; Leuenberger, Michele; Preti, Barbara; Tesfazghi, Bereket; Bartlome, Pascal; Frenguelli, Bruno G.; Barkan-Bulman, Kerry; Ladds, Graham (10 September 2018). Development of Molecular Tools for the Study of Adenosine A1 Receptors (Unpublished). In: 7th RSC/SCI Symposium on GPCRs in Medicinal Chemistry. Verona. 10.-12.09.2018.

Preti, Barbara; Tesfazghi, Bereket; Bartlome, Pascal; Leuenberger, Michele; Frenguelli, Bruno G.; Ladds, Graham; Lochner, Martin (7 September 2018). Molecular Tools for the Cellular Study of Adenosine A1 Receptors. CHIMIA, 72(7/8). Schweizerische Chemische Gesellschaft

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (7 September 2018). Study of 2-Aminoethoxy Borate (2-APB) Analogues in MDA-MB-231 and MCF-7 Cells towards Orai Isoform-specific Modulation of Store-operated Calcium Entry (SOCE). CHIMIA, 72(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (7 September 2018). Synthesis of Functionalised Probes Based on GSK7975A to Study SOCE. CHIMIA, 72(7/8). Schweizerische Chemische Gesellschaft

Leuenberger, Michele; Bernhard, Stephanie; Stieger, Bruno; Lochner, Martin (21 August 2017). Fluorescent Bile Salt Derivatives for the Investigation of the Canalicular Lipid Transporter System. CHIMIA, 71(7/8). Schweizerische Chemische Gesellschaft

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (21 August 2017). Diaryl Boronic Acid Modulate Store-operated Calcium Entry (SOCE). CHIMIA, 71(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (21 August 2017). Synthesis of Novel Probes based on GSK7975A to study SOCE. CHIMIA, 71(7/8). Schweizerische Chemische Gesellschaft

Lochner, Martin; Hemmings, Jennifer Luise; Leuenberger, Michele; Meyer, Jonas; Bartlome, Pascal; Perozzo, Alyssa Victoria; Frenguelli, Bruno G.; Winfield, Ian; Ladds, Graham (12 February 2017). Molecular Tools for the Cellular Study of Adenosine A1 Receptors (Unpublished). In: GDCh/SCS conference on Frontiers in Medicinal Chemistry. Bern. 12.-15.02.2017.

Leuenberger, Michele; Lochner, Martin; Bernhard, Stephanie; Stieger, Bruno (12 February 2017). Synthesis of Fluorescent Bile Salt Derivatives and Their Utility as Tracers of the Canalicular Lipid Transporter System (Unpublished). In: GDCh/SCS conference on Frontiers in Medicinal Chemistry. Bern. 12.-15.2.2017.

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Leuenberger, Michele; Rüefli, Pascal; Bur-Cecilio Hechavarria, Yamileidi; Ruepp, Marc-David; Thompson, Andrew J. (August 2016). Investigation of the interaction between 5-HT3R and its modulators: progress in understanding the agonist binding site. CHIMIA, 70(7/8), MC121. Schweizerische Chemische Gesellschaft

Leuenberger, Michele; Ritler, Andreas; Aerni, Valerie; Metzger, Simon G.; Ruepp, Marc-David; Lochner, Martin (August 2016). New insights into glutamate transport in brain: Concise asymmetric synthesis of TFB-TBOA and photoaffinity probes. CHIMIA, 70(7/8), MC123. Schweizerische Chemische Gesellschaft

Schild, Achille; Tscherrig, Dominic Armin; Wenger, Nicolas; Rajesh, Rajesh; Lüscher, Benjamin; Hediger, Matthias; Lochner, Martin (August 2016). Design, synthesis and pharmacological characterization of novel store-operated calcium channel (SOCE) modulators. CHIMIA, 70(7/8), MC125. Schweizerische Chemische Gesellschaft

Hemmings, Jennifer Luise; Lochner, Martin (August 2015). Development of small molecular tools for the cellular study of adenosine A1 receptors. CHIMIA, 69(7/8), p. 467. Schweizerische Chemische Gesellschaft

Simonin, Jonathan; Lochner, Martin (August 2015). Fluorescent probes for the cellular study of the 5-HT3A receptor - synthesis and evaluation of near-infrared probes. CHIMIA, 69(7/8), p. 467. Schweizerische Chemische Gesellschaft

Jack, Thomas; Lochner, Martin (August 2015). Synthesis of photo-crosslinking probes and their application for the site-selective chemical modification of the 5-HT3 receptor. CHIMIA, 69(7/8), p. 468. Schweizerische Chemische Gesellschaft

Lochner, Martin; Hemmings, Jennifer Luise; Knight, Anthony; Frenguelli, Bruno G.; Ladds, Graham (15 June 2015). Development of small molecular tools for the cellular study of adenosine receptors (Unpublished). In: Challenges in Chemical Biology (ISACS16). ETH Zürich, Hönggerberg, Switzerland. 15.06.-18.06.2015.

Leuenberger, Michele; Jack, Thomas; Ruepp, Marc-David; Lagache, Sophie; Heller, Manfred; Mühlemann, Oliver; Thompson, Andrew J.; Lochner, Martin (15 June 2015). Synthesis of photo-crosslinking probes and their application for the site-selective chemical modification of the 5-HT3 receptor (Unpublished). In: Challenges in Chemical Biology (ISACS16). Book of Abstracts. ETH Zürich, Hönggerberg, Switzerland. 15.06.-18.06.2015.

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Ruepp, Marc-David; Leuenberger, Michele; Hemmings, Jennifer Luise; Singhanat, Suradech; Thompson, Andrew James (2 October 2014). Studying Ion Channels and Receptors Using Synthetic Molecular Probes (Unpublished). In: 3rd Swiss-Japanese Chemical Biology Symposium. Bern, Switzerland. 02.-03.10.2014.

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Leuenberger, Michele; Ruepp, Marc-David; Hemmings, Jennifer Luise; Thompson, Andrew James (20 August 2014). Synthesis of Molecular Tools for the Cellular Study of Ion Channels and Receptors (Unpublished). In: EMBO Conference Chemical Biology. Heidelberg, Germany. 20.-23.08.2014.

Jack, Thomas; Lochner, Martin (August 2014). Site-selective chemical modification of the 5-HT3 receptor with newly developed photo-crosslinking probes. CHIMIA, 68(7/8), p. 552. Schweizerische Chemische Gesellschaft

Leuenberger, Michele; Lochner, Martin (August 2014). Synthesis of inhibitors and probes for the cellular study of glutamate transporters. CHIMIA, 68(7/8), p. 552. Schweizerische Chemische Gesellschaft

Simonin, Jonathan; Lochner, Martin (August 2014). Fluorescent probes for the cellular study of the 5-HT3A receptor - development of binding assay and in-vivo imaging. CHIMIA, 68(7/8), p. 553. Schweizerische Chemische Gesellschaft

Hemmings, Jennifer Luise; Lochner, Martin (July 2014). Novel fluorescent agonists for the A1 adenosine receptor. CHIMIA, 68(7/8), p. 552. Schweizerische Chemische Gesellschaft

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Leuenberger, Michele; Hemmings, Jennifer Luise; Singhanat, Suradech (24 January 2014). Toolomics - Molecular Probes for Studying and Modification of Ion Channels and Receptors (Unpublished). In: 12th Swiss Snow Symposium. Saas-Fee, Switzerland. 24.01.2014.

Jack, Thomas; Ruepp, Marc-David; Mühlemann, Oliver; Thompson, Andrew James; Lummis, Sarah C. R.; Lochner, Martin (August 2013). Synthesis and testing of photoaffinity probes for the site-selective chemical modification of the 5-HT3 receptor. CHIMIA, 67(7/8), p. 519. Schweizerische Chemische Gesellschaft

Simonin, Jonathan; Jack, Thomas; Ruepp, Marc-David; Hothersall, Daniel; Connolly, Christopher; Chicca, Andrea; Gertsch, Jürg; Thompson, Andrew James; Lummis, Sarah C. R.; Lochner, Martin (August 2013). Synthesis of fluorescent probes for the study of the 5-HT3 receptor: applications in imaging and fluorescence polarization. CHIMIA, 67(7/8), p. 524. Schweizerische Chemische Gesellschaft

Hemmings, Jennifer Luise; Ladds, Graham; Knight, Anthony; Frenguelli, Bruno G.; Lochner, Martin (August 2013). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. CHIMIA, 67(7/8), p. 532. Schweizerische Chemische Gesellschaft

Singhanat, Suradech; Ruepp, Marc-David; Jack, Thomas; Rougier, Jean-Sébastien; Abriel, Hugues; Mühlemann, Oliver; Lochner, Martin (August 2013). Towards the site-specific modification of the hERG K+ channel. CHIMIA, 67(7/8), p. 532. Schweizerische Chemische Gesellschaft

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Hemmings, Jennifer Luise; Leuenberger, Michele; Ruepp, Marc-David; Thompson, Andrew James (9 June 2013). Synthesis of Molecular Tools for the Cellular Study of Ion Channels and Receptors (Unpublished). In: Gordon Research Conference Bioorganic Chemistry. Andover, NH, USA. 09.-14.06.2013.

Lochner, Martin; Jack, Thomas; Simonin, Jonathan; Singhanat, Suradech; Hemmings, Jennifer Luise; Leuenberger, Michele; Thompson, Andrew James; Ruepp, Marc-David (26 April 2013). Chemical Tools for the Study and Modification of Ion Channels and Receptors (Unpublished). In: BioChemLig Meeting. Bern. 26.04.2013.

Hemmings, Jennifer L.; Frenguelli, Bruno G.; Lochner, Martin (2012). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. In: CUSO summer school "Chemical Biology" book of abstracts.

Jack, Thomas; Lochner, Martin (2012). Synthesis and testing of photoaffinity probes for the site-selective chemical modifications of the 5-HT3 receptor. In: CUSO summer school "Chemical Biology" book of abstracts.

Simonin, Jonathan; Chicca, Andrea; Gertsch, Jürg; Lochner, Martin (2012). High affinity fluorescent probes to study the 5-HT3 receptor: applications in imaging and flow cytometry. In: CUSO summer school "Chemical Biology" book of abstracts.

Singhanat, Suradech; Rougier, Jean-Sébastien; Abriel, Hugues; Lochner, Martin (2012). Towards the site-specific modification of the hERG channel. In: CUSO summer school "Chemical Biology" book of abstracts.

Simonin, Jonathan; Chicca, Andrea; Gertsch, Jürg; Lochner, Martin (2012). High affinity fluorescent probes to study the 5-HT3 receptor: applications in imaging and flow cytometry. CHIMIA, 66(7/8), p. 558. Bern: Schweizerische Chemische Gesellschaft

Jack, Thomas; Lochner, Martin (2012). Synthesis and testing of photoaffinity probes for the site-selective chemical modifications of the 5-HT3 receptor. CHIMIA, 66(7/8), p. 558. Bern: Schweizerische Chemische Gesellschaft

Hemmings, Jennifer L.; Frenguelli, Bruno G.; Lochner, Martin (2012). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. CHIMIA, 66(7-8), p. 314. Bern: Schweizerische Chemische Gesellschaft

Hofer, Alexandre; Leuenberger, Michele; Kovacs, Gergely; Hediger, Matthias A.; Lochner, Martin (2012). Synthesis of 2-APB analogues as inhibitors of TRPV6-mediated Calcium transport. CHIMIA, 66(7-8), p. 558. Bern: Schweizerische Chemische Gesellschaft

Singhanat, Suradech; Rougier, Jean-Sébastien; Abriel, Hugues; Lochner, Martin (2012). Towards the site-specific modification of the hERG channel. CHIMIA, 66(7/8), p. 559. Bern: Schweizerische Chemische Gesellschaft

Lochner, Martin (2012). Synthese von molekularen Werkzeugen zur Untersuchung von Ionenkanälen. In: Memorialsymposium zum Gedenken an Prof. M. Hesse, Universität Zürich.

Hemmings, Jennifer L.; Frenguelli, Bruno G.; Lochner, Martin (2012). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. In: Challenges in Organic Chemistry and Chemical Biology (ISACS7), Edinburgh, book of abstracts.

Leuenberger, Michele; Lochner, Martin (2012). Developing chemical tools for the study of transporters. In: Institute of Biochemistry and Molecular Medicine mini-symposium, University of Bern.

Hemmings, Jennifer L.; Frenguelli, Bruno G.; Lochner, Martin (2012). Synthesis of novel fluorescent agonists, with selectivity for the A1 adenosine receptor. In: CUSO subject day "Chemical Biology", University of Basel, book of abstracts.

Lochner, Martin (16 June 2011). Molecular Tools for the Biological Study of Ion Channels (Unpublished). In: Young Faculty Meeting of the Swiss Academy of Sciences (Platform Chemistry). Bern. 16.06.2011.

Lochner, Martin; Hallaq, Hasan Y.; Menary, Jennifer; Stephenson, James D.; Vernekar, Sanjeev K.; Thompson, Andrew J.; Lummis, Sarah C. R. (5 June 2009). Synthetic Neuroscience - Towards the Chemical Modification of a Ligand-gated Ion Channel Receptor (Unpublished). In: RSC/BPS conference 'Ion Channels as Therapeutic Targets'. Horsham, UK. 05.-06.02.2009.

Lochner, Martin (23 September 2008). Synthetic Neuroscience -Towards the Chemical Modification of a Ligand-gated Ion Channel Receptor (Unpublished). In: RSC Bio-Organic Group Forum (BOG-F1). Leicester, UK. 23.09.2008.

Lochner, Martin (28 September 2007). Towards the chemical modification of the serotonin 5-HT3 receptor (Unpublished). In: Gregynog Synthesis Workshop. Gregynog, Wales, UK. 28.-30.09.2007.

Lochner, Martin (6 July 2005). Structural and Functional Study of the Serotonin 5-HT3A/B Receptor Binding Site (Unpublished). In: British Pharmacology Society Summer Meeting. Cambridge, UK. 06.-08.07.2005.

Lochner, Martin (1 June 2005). Models for Ligand-gated Ion Channels - Structural and Functional Study of the Serotonin 5-HT3A/B Receptor Binding Site (Unpublished). In: Young Chemists Workshop/CERC3 meeting 'Biophysical Chemistry Meets Molecular Medicine'. Sesimbra, Portugal. 01.-04.06.2005.

Lochner, Martin; Atkinson, Stephen J.; Di Francesco, Maria Emilia; Kühn, Toralf; Lorenz, Katrin; Paterson, Ian (2005). Studies towards the total synthesis of peloruside A. In: 229th ACS Spring National Meeting, Abstracts of Papers of the American Chemical Society. San Diego, Californien. 13.03.-17.03.2005.

Lochner, Martin (7 October 2004). Studies Towards the Total Synthesis of (+)-Peloruside A (Unpublished). In: Fall Meeting of the Swiss Chemical Society. Zürich. 07.10.2004.

Lochner, Martin (13 September 2004). Studies Towards the Total Synthesis of (+)-Peloruside A (Unpublished). In: Young Scientists Conference on Bioorganic Chemistry. Hamburg, Germany. 13.-15.09.2004.

Lochner, Martin; Atkinson, Stephen J.; Di Francesco, Emilia M.; Kühn, Toralf; Paterson, Ian (17 April 2004). Studies Towards the Total Synthesis of (+)-Peloruside A (Unpublished). In: 39. EUCHEM Bürgenstock Conference on Stereochemistry. Bürgenstock, Switzerland. 17.-23.04.2004.

Lochner, Martin (17 October 2002). A Crown-Capped Iron Porphyrin Mimicking the Resting State of Cytochrome P450cam (Unpublished). In: Fall Meeting of the Swiss Chemical Society. Basel, Switzerland. 17.10.2002.

Lochner, Martin; Woggon, Wolf-D. (25 September 2002). A Crown-Capped Iron Porphyrin Mimicking the Resting State of Cytochrome P450cam (Unpublished). In: 22. Regiosymposium of Organic and Bioorganic Chemistry. Falkau-Feldberg, Germany. 25.-27.09.2002.

Lochner, Martin (12 October 2001). A Novel Iron Porphyrin Mimicking the Resting State of Cytochrome P450cam (Unpublished). In: Fall Meeting of the Swiss Chemical Society. Zürich, Switzerland. 12.10.2001.

Lochner, Martin; Mu, Linjing; Müller, Michael; Woggon, Wolf-D. (8 March 2001). Synthesis of an Active Site Analogue of the Resting State of Cytochrome P450cam (Unpublished). In: 4th Lausanne Conference on Bioorganic Chemistry. Lausanne, Switzerland. 08.-09.03.2001.

Working Paper

Wall, Mark J.; Hill, Emily; Huckstepp, Robert; Deganutti, Giuseppe; Leuenberger, Michele; Preti, Barbara; Barkan, Kerry; Winfield, Ian; Wei, Haifeng; Imlach, Wendy; Dean, Eve; Hume, Cherise; Hayward, Stephanie; Oliver, Jess; Zhao, Fei-Yue; Spanswick, David; Reynolds, Christopher A.; Lochner, Martin; Ladds, Graham and Frenguelli, Bruno G. (5 April 2020). Non-opioid analgesia based on Galpha signalling bias (Submitted) Cold Spring Harbor Laboratory 10.1101/2020.04.04.023945

Journal or Series

Lochner, Martin; Thompson, Andrew J. (eds.) (2015). Fluorescent Tools in Neuropharmacology. Special Issue of Neuropharmacology, 98. Elsevier

  • Schweizerische Chemische Gesellschaft
  • Royal Society of Chemistry (MRSC)